Taking
BEQALZI
STARTING BEQALZI
WHEN TAKING BEQALZI
Take tablets with a GLASS OF WATER DURING A MEAL, once a day, at about the same time each day.
SWALLOW TABLETS WHOLE Do not break, chew, or crush.
STAY WELL HYDRATED Drink 6 to 8 glasses (~51-68 oz) of water daily, starting 1 to 2 days before your first dose, on the day of your first dose, during dose increases, and if treatment is restarted.
Ensure adequate hydration throughout treatment.
Some patients may need hospitalization for intravenous (IV) fluids and closer monitoring.
KEEP TABLETS IN THE ORIGINAL STARTER PACKAGING
for the first 4 weeks of treatment.
BEQALZI Patient Dosing Guide
Use this convenient resource with helpful information as you get started on BEQALZI.
Download
BEQALZI DOSING SCHEDULE
The dosage for BEQALZI starts low and gradually increases over the first 4 weeks to help your body acclimate to the medication. This ramp-up period helps reduce the risk of tumor lysis syndrome (TLS), which is a serious side effect caused by the fast breakdown of cancer cells.
4-week ramp up
-
During the ramp-up, you will take a single tablet on Day 1 to
Day 3 of each week, increasing to 2 tablets on Day 4 to Day 7 of each week - Your dose will gradually increase from 1 mg to 160 mg during these 4 weeks
- Use this dosing calendar to track your progress
| Days 1-3 |
Days 4-7 |
|
|---|---|---|
|
Week 1 |
1 mg
|
2 mg
(1 mg x 2 taken together)
|
|
Week 2 |
5 mg
|
10 mg
(5 mg x 2 taken together)
|
|
Week 3 |
20 mg
|
40 mg
(20 mg x 2 taken together)
|
|
Week 4 |
80 mg
|
160 mg
(80 mg x 2 taken together)
|
Ongoing treatment
- After the 4-week ramp-up period, the ongoing daily dose, 320 mg (four 80 mg tablets), begins on Day 1 of Week 5
- You will stay on this dose as long as it is helpful for you. Your healthcare provider will work with you to monitor your progress and help manage any side effects you may have
If you miss a dose
If a dose is missed WITHIN 8 HOURS, take dose with a meal as soon as possible and resume normal schedule
If it has been MORE THAN 8 HOURS, do not take dose; resume normal schedule the following day
DO NOT change your dose of BEQALZI or stop taking BEQALZI unless your healthcare provider tells you to
If you vomit after taking BEQALZI, DO NOT TAKE AN EXTRA DOSE. Take the next dose at your usual time the next day
DO NOT restart BEQALZI on your own if your healthcare provider has stopped treatment
If you have questions regarding a missed dose, SPEAK WITH YOUR HEALTHCARE PROVIDER
HELP REDUCE THE RISK OF TLS
Dose ramp-up and hydration may help reduce TLS risk
The gradual 4-week ramp-up may help reduce the risk of tumor lysis syndrome (TLS), which is a serious side effect caused by the fast breakdown of cancer cells which can cause kidney failure, the need for dialysis treatment, and can be life-threatening. Because of this, it is important to follow the ramp-up dosing instructions carefully.
Ramp-up reminders
Drink 6 to 8 glasses (~51-68 oz) of water daily, starting 1 to 2 days before your first dose, on the day of your first dose, during dose increases, and if treatment is restarted. Ensure adequate hydration throughout treatment. Some patients may need hospitalization for intravenous (IV) fluids and closer monitoring.
Your healthcare provider will prescribe medications before the first dose of BEQALZI to reduce the risk of TLS. Your healthcare provider may suggest additional medications based on your TLS lab results.
Monitoring during treatment
- You will have regular blood tests to check your tumor and kidney function
- Some patients, including those with high TLS risk, may need hospitalization for IV fluids and closer monitoring
